BDBM458335 4-(((1R,5S,8s)-3-benzyl-3-azabicyclo[3.2.1]octan-8-yl)(methyl)amino)-5-chloro-N-(6-fluoropyridin-2-yl)thiophene-2-sulfonamide trifluoroacetic acid salt::US10752623, Example 55

SMILES CN([C@H]1[C@H]2CC[C@@H]1CN(Cc1ccccc1)C2)c1cc(sc1Cl)S(=O)(=O)Nc1cccc(F)n1

InChI Key InChIKey=DOYNLCGEBFAONQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458335   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458335(4-(((1R,5S,8s)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 38nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458335(4-(((1R,5S,8s)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 2.48E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458335(4-(((1R,5S,8s)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 3.99E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent