BDBM458336 4-((1-benzylpiperidin-4-yl)(methyl)amino)-5-ethyl-N-(6-fluoropyridin-2-yl)thiophene-2-sulfonamide::US10752623, Example 56

SMILES CCc1sc(cc1N(C)C1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1cccc(F)n1

InChI Key InChIKey=IKXSTKZJRJBHQY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458336   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458336(4-((1-benzylpiperidin-4-yl)(methyl)amino)-5-ethyl-...)
Affinity DataIC50: 131nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458336(4-((1-benzylpiperidin-4-yl)(methyl)amino)-5-ethyl-...)
Affinity DataIC50: 4.70E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458336(4-((1-benzylpiperidin-4-yl)(methyl)amino)-5-ethyl-...)
Affinity DataIC50: 1.02E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent