BDBM458339 5-((1-benzylpiperidin-4-yl)(methyl)amino)-N-(thiazol-4-yl)-4-(trifluoromethyl)pyridine-2-sulfonamide trifluoroacetic acid salt::US10752623, Example 59

SMILES CN(C1CCN(Cc2ccccc2)CC1)c1cnc(cc1C(F)(F)F)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=VBJIDHLXTVKFSL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458339   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458339(5-((1-benzylpiperidin-4-yl)(methyl)amino)-N-(thiaz...)
Affinity DataIC50: 26nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458339(5-((1-benzylpiperidin-4-yl)(methyl)amino)-N-(thiaz...)
Affinity DataIC50: 7.62E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458339(5-((1-benzylpiperidin-4-yl)(methyl)amino)-N-(thiaz...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent