BDBM458343 5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8-yl)(methyl)amino)-3-fluoro-N-(6-fluoropyridin-2-yl)-4-methylpyridine-2-sulfonamide trifluoroacetic acid salt::US10752623, Example 63

SMILES CN([C@@H]1[C@H]2CC[C@@H]1CN(Cc1ccccc1)C2)c1cnc(c(F)c1C)S(=O)(=O)Nc1cccc(F)n1

InChI Key InChIKey=TUUXTJIIKIZEEU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458343   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458343(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 213nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458343(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458343(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent