BDBM458370 US10752631, Compound 1

SMILES COc1cc(OC)cc(c1)C#Cc1nc([C@H]2CCN(C2)C(=O)C=C)n2ccnc(N)c12

InChI Key InChIKey=VZXCNANMEQQUMK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 458370   

TargetFibroblast growth factor receptor 2(Human)
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM458370(US10752631, Compound 1)
Affinity DataIC50: 50nMAssay Description:The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTRF kina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM458370(US10752631, Compound 1)
Affinity DataIC50: 50nMAssay Description:The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTRF kina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM458370(US10752631, Compound 1)
Affinity DataIC50: 275nMAssay Description:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTRF kina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM458370(US10752631, Compound 1)
Affinity DataIC50: 275nMAssay Description:The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTRF (Hom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent