BDBM458517 4-((2-((7-azabicyclo[2.2.1]heptan-7-yl)methyl)-3,6-difluorobenzyl)amino)-2,6-difluoro-N-(thiazol-4-yl)benzenesulfonamide::US10745392, Example 10::US11325902, Example 10

SMILES Fc1ccc(F)c(CN2C3CCC2CC3)c1CNc1cc(F)c(c(F)c1)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=BXARZHIBGXYSKK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 458517   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458517(4-((2-((7-azabicyclo[2.2.1]heptan-7-yl)methyl)-3,6...)
Affinity DataIC50: 28nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458517(4-((2-((7-azabicyclo[2.2.1]heptan-7-yl)methyl)-3,6...)
Affinity DataIC50: 2.54E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458517(4-((2-((7-azabicyclo[2.2.1]heptan-7-yl)methyl)-3,6...)
Affinity DataIC50: 7.93E+3nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458517(4-((2-((7-azabicyclo[2.2.1]heptan-7-yl)methyl)-3,6...)
Affinity DataIC50: 28nMAssay Description:The following patch voltage clamp electrophysiology studies may be performed on representative compounds of the invention using human embryonic kidne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458517(4-((2-((7-azabicyclo[2.2.1]heptan-7-yl)methyl)-3,6...)
Affinity DataIC50: 2.54E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458517(4-((2-((7-azabicyclo[2.2.1]heptan-7-yl)methyl)-3,6...)
Affinity DataIC50: 7.93E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent