BDBM458774 US10759766, Compound C109

SMILES Fc1cc(NC(=O)c2cccc(c2)C(F)(F)F)c(F)c(C(=O)c2ccc3nccnc3c2)c1F

InChI Key InChIKey=SEIFCFIHLZOVAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 458774   

TargetVascular endothelial growth factor receptor 2(Human)
Neupharma

US Patent
LigandPNGBDBM458774(US10759766, Compound C109)
Affinity DataIC50: 100nMAssay Description:KDR (VEGFR2): Inhibitory activities of compounds against KDR (VEGFR2) were also measured by Invitrogen using Z′-LYTE Method as described above ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Neupharma

US Patent
LigandPNGBDBM458774(US10759766, Compound C109)
Affinity DataIC50: 100nMAssay Description:BRAF and BRAF V600E: Inhibitory activities Inhibitory activities of compounds against BRAF, and BRAF V600E were measured by Invitrogen using Z′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent