BDBM458827 6-((Cyclopropylmethyl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)amino)-5-ethyl-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzofuran-4-carboxamide 34::US10759787, Example 34::US11059811, Example 34

SMILES CCc1c(cc2occc2c1C(=O)NCc1c(OC)cc(C)[nH]c1=O)N(CC1CC1)C1CCN(CC(F)(F)F)CC1

InChI Key InChIKey=PKQIGNIDFOQGPY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 458827   

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458827(6-((Cyclopropylmethyl)(1-(2,2,2-trifluoroethyl)pip...)
Affinity DataIC50: 14nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458827(6-((Cyclopropylmethyl)(1-(2,2,2-trifluoroethyl)pip...)
Affinity DataIC50: 14nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent