BDBM458828 6-(((1r,4r)-4-(Dimethylamino)cyclohexyl)(ethyl)amino)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-methylbenzofuran-4-carboxamide::US10759787, Example 24::US11059811, Example 24

SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc2occc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C

InChI Key InChIKey=RUNKGINRWPJDJS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 458828   

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458828(6-(((1r,4r)-4-(Dimethylamino)cyclohexyl)(ethyl)ami...)
Affinity DataIC50: 3.40nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM458828(6-(((1r,4r)-4-(Dimethylamino)cyclohexyl)(ethyl)ami...)
Affinity DataIC50: 3.40nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent