BDBM459532 US10772893, Example 41::US11529356, Example 41

SMILES CC(C)Oc1cc(nc2c(nccc12)-c1ccc[nH]1)N1CCOCC1

InChI Key InChIKey=GRZNEMLYJKJTIU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 459532   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM459532(US10772893, Example 41 | US11529356, Example 41)
Affinity DataIC50: 230nMAssay Description:To determine of binding activity of the test compounds, full-length human ATR protein was expressed and purified together with ATRIP as described abo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM459532(US10772893, Example 41 | US11529356, Example 41)
Affinity DataIC50: 230nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM459532(US10772893, Example 41 | US11529356, Example 41)
Affinity DataIC50: 339nMAssay Description:To determine of binding activity of the test compounds, full-length human ATR protein was expressed and purified together with ATRIP as described abo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM459532(US10772893, Example 41 | US11529356, Example 41)
Affinity DataIC50: 339nMAssay Description:Inhibition of 5'-TAMRA-labeled tracer 3',6'-bis(dimethylamino)-N-(4-{[2(1H-indol-4-yl)-6-(morpholin-4-yl)-pyrimidin-4-yl]amino}butyl)-3-oxo-3H-spiro[...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM459532(US10772893, Example 41 | US11529356, Example 41)
Affinity DataIC50: 339nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM459532(US10772893, Example 41 | US11529356, Example 41)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as reduction in histone H2AX phosphorylation measured after 30 mins by immunofluorescence cytometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed