BDBM4621 Anilinoquinazoline deriv. 4::CHEMBL150315::N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

SMILES COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC

InChI Key InChIKey=YHUIUSRCUKUUQA-UHFFFAOYSA-N

Data  13 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 4621   

LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 2.00E+3nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 100nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 7.00E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Protana

Curated by ChEMBL
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Protana

Curated by ChEMBL
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataKd:  6.20E+3nMAssay Description:Equilibrium binding constant for EPH receptor B2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory activity against VEGFR2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against flt kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of VEGFR1 expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of VEGFR1 phosphorylation in human A498 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of VEGFR1 tyrosine kinase activity in VEGF-stimulated human A498 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of VEGF-induced VEGFR1 autophosphorylation in human A498 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of VEGF-induced VEGFR1 phosphorylation in human A498 cells overexpressing Flt-1 pretreated for 60 mins prior to VEGF addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM4621(N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazoli...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of VEGFR1 in human A498 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed