BDBM4633 2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy)quinolin-4-yl]amino}phenol::Anilinoquinoline deriv. 16::N-(4-Chloro-2-fluoro-5-hydroxyphenyl)-6-methoxy-7-(2-methoxyethoxy)-4-quinolinylamine hydrochloride

SMILES COCCOc1cc2nccc(Nc3cc(O)c(Cl)cc3F)c2cc1OC

InChI Key InChIKey=QGRWLEOULVUBBC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4633   

LigandPNGBDBM4633(N-(4-Chloro-2-fluoro-5-hydroxyphenyl)-6-methoxy-7-...)
Affinity DataIC50: 2nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4633(N-(4-Chloro-2-fluoro-5-hydroxyphenyl)-6-methoxy-7-...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4633(N-(4-Chloro-2-fluoro-5-hydroxyphenyl)-6-methoxy-7-...)
Affinity DataIC50: 1.40E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed