BDBM4636 4-anilinocinnoline deriv. 19::CHEMBL150825::N-(4-chloro-2-fluorophenyl)-6-methoxy-7-(2-methoxyethoxy)cinnolin-4-amine

SMILES COCCOc1cc2nncc(Nc3ccc(Cl)cc3F)c2cc1OC

InChI Key InChIKey=DUQXHJPGYOWVMD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 4636   

TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM4636(CHEMBL150825 | N-(4-chloro-2-fluorophenyl)-6-metho...)
Affinity DataIC50: 10nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM4636(CHEMBL150825 | N-(4-chloro-2-fluorophenyl)-6-metho...)
Affinity DataIC50: 10nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM4636(CHEMBL150825 | N-(4-chloro-2-fluorophenyl)-6-metho...)
Affinity DataIC50: 1.10E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4636(CHEMBL150825 | N-(4-chloro-2-fluorophenyl)-6-metho...)
Affinity DataIC50: 1.40E+4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4636(CHEMBL150825 | N-(4-chloro-2-fluorophenyl)-6-metho...)
Affinity DataIC50: 6.30E+4nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed