BDBM4640 Anilinoquinazoline deriv. 23::N-(4-Chloro-2-fluorophenyl)-6-methoxy-7-[4-(4-morpholinyl)-butoxy]-4-quinazolinylamine hydrochloride::N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[4-(morpholin-4-yl)butoxy]quinazolin-4-amine

SMILES COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCCN1CCOCC1

InChI Key InChIKey=HFMHGWWJWDMFFN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4640   

LigandPNGBDBM4640(N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[4-(morpho...)
Affinity DataIC50: 40nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4640(N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[4-(morpho...)
Affinity DataIC50: 300nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4640(N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[4-(morpho...)
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed