BDBM464240 3-(4-(1H-pyrazol-4- yl)phenyl)-1-(3- methoxybenzyl)-8- (3,3,3- trifluoropropyl)-1,3,8- triazaspiro[4.5]decan- 2-one::US10787450, Example 121

SMILES COc1cccc(CN2C(=O)N(CC22CCN(CCC(F)(F)F)CC2)c2ccc(cc2)-c2cn[nH]c2)c1

InChI Key InChIKey=XLFDPQNOILAEGC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464240   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464240(3-(4-(1H-pyrazol-4- yl)phenyl)-1-(3- methoxybenzyl...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent