BDBM464418 US10787457, Example 51::US11014930, Example 51::US11236096, Example 51

SMILES Cc1cc(n[nH]1)NC(=O)c2cn(c3c2c(ncn3)N)C4(CC4)C

InChI Key InChIKey=VKNSWNWSJODLGL-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 464418   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11236096, Example 51 | ...)
Affinity DataIC50: 0.170nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11236096, Example 51 | ...)
Affinity DataIC50: 0.170nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11236096, Example 51 | ...)
Affinity DataIC50: 0.170nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11236096, Example 51 | ...)
Affinity DataIC50: 8.70nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against SRC kinase activity, the price list of LabChip-series c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11236096, Example 51 | ...)
Affinity DataIC50: 1.22E+3nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against LCK kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent