BDBM464611 CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-phenyl-3-tetrahydro-pyran-4-yl- 1,3-diazaspiro[4.5]decan-2-one::US10793556, Example SC_4040::US10793556, Example SC_4041::US10793556, Example SC_4042::US10793556, Example SC_4043

SMILES CN(C)[C@]1(CC[C@]2(CN(CC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1

InChI Key InChIKey=RFRXGGJNTCDYAY-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 464611   

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464611(US10793556, Example SC_4040 | US10793556, Example ...)
Affinity DataKi:  4nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464611(US10793556, Example SC_4040 | US10793556, Example ...)
Affinity DataKi:  4nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464611(US10793556, Example SC_4040 | US10793556, Example ...)
Affinity DataKi:  11nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464611(US10793556, Example SC_4040 | US10793556, Example ...)
Affinity DataKi:  19nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464611(US10793556, Example SC_4040 | US10793556, Example ...)
Affinity DataKi:  124nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464611(US10793556, Example SC_4040 | US10793556, Example ...)
Affinity DataKi:  125nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464611(US10793556, Example SC_4040 | US10793556, Example ...)
Affinity DataKi:  270nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464611(US10793556, Example SC_4040 | US10793556, Example ...)
Affinity DataKi:  290nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent