BDBM465731 2-[3-(2-amino-7H-pyrrolo[2,3- d]pyrimidin-4-yl)-2-(hydroxy- methyl)phenyl]-6-cyclopropyl-8- fluoroisoquinolin-1(2H)-one::US10793575, Example 6

SMILES Nc1nc(-c2cccc(c2CO)-n2ccc3cc(cc(F)c3c2=O)C2CC2)c2cc[nH]c2n1

InChI Key InChIKey=BRMJBKINVMDEDX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 465731   

TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

US Patent
LigandPNGBDBM465731(US10793575, Example 6 | 2-[3-(2-amino-7H-pyrrolo[2...)
Affinity DataIC50: 10nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

US Patent
LigandPNGBDBM465731(US10793575, Example 6 | 2-[3-(2-amino-7H-pyrrolo[2...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed