BDBM465732 2-[3-(2-amino-6-methyl- 7H-pyrrolo[2,3- d]pyrimidin-4-yl)-2- (hydroxymethyl)phenyl]- 6-cyclopropyl-8- fluoroisoquinolin-1(2H)-one::US10793575, Example 7

SMILES Cc1cc2c(nc(N)nc2[nH]1)-c1cccc(c1CO)-n1ccc2cc(cc(F)c2c1=O)C1CC1

InChI Key InChIKey=MWUBYBSKWWPCAM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 465732   

TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

US Patent
LigandPNGBDBM465732(US10793575, Example 7 | 2-[3-(2-amino-6-methyl- 7H...)
Affinity DataIC50: 10nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

US Patent
LigandPNGBDBM465732(US10793575, Example 7 | 2-[3-(2-amino-6-methyl- 7H...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed