BDBM466078 US10793580, Example 181::[(2R)-3-(1-ethyl-8-oxo- spiro[6,7-dihydro-4H- pyrazolo[3,4-c]azepine- 5,4'-tetrahydropyran]-3- yl)-2-methyl-propyl] 3- (pyrrolidine-1- carbonyl)benzoate

SMILES CCn1nc(C[C@@H](C)COC(=O)c2cccc(c2)C(=O)N2CCCC2)c2CC3(CCOCC3)CNC(=O)c12

InChI Key InChIKey=QVHYBHPKWMFBSV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 466078   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Leo Pharma

US Patent
LigandPNGBDBM466078([(2R)-3-(1-ethyl-8-oxo- spiro[6,7-dihydro-4H- pyra...)
Affinity DataIC50: 100nMAssay Description:The human PDE4D catalytic domain (UniProt no. Q08499 [S380-L740]) was incubated with a mixture of non-labelled cAMP (cyclic adenosine monophosphate) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent