BDBM4664 4-Anilinoquinazoline 11::N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-{[(2E)-4-pyrrolidin-1-ylbut-2-enyl]oxy}quinazolin-4-amine::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(2E)-4-(pyrrolidin-1-yl)but-2-en-1-yl]oxy}quinazolin-4-amine

SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC\C=C\CN1CCCC1

InChI Key InChIKey=ZMAGOHAYMIZJEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4664   

LigandPNGBDBM4664(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(2E)-4-(p...)
Affinity DataIC50: 8nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

LigandPNGBDBM4664(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(2E)-4-(p...)
Affinity DataIC50: 100nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4664(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(2E)-4-(p...)
Affinity DataIC50: 650nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4664(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(2E)-4-(p...)
Affinity DataIC50: 2.10E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed