BDBM466668 US10800757, Compound 83::US10889568, Compound 83::[4-(6-Amino-pyridazin-3-yl)-piperidin- 1-yl]-[5-(phenoxy)-4-ethoxy-pyridin-2- yl]-methanone

SMILES CCOc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1

InChI Key InChIKey=KPBROUBVBSSABA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466668   

TargetShort transient receptor potential channel 6(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466668(US10889568, Compound 83 | [4-(6-Amino-pyridazin-3-...)
Affinity DataIC50: 98nMAssay Description:This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetShort transient receptor potential channel 6(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466668(US10889568, Compound 83 | [4-(6-Amino-pyridazin-3-...)
Affinity DataIC50: 98nMAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent