BDBM46667 2-phenyl-1,2-benzothiazol-3-one::2-phenyl-1,2-benzothiazol-3-one (1)::MLS-0107957.0001::acs.jmedchem.1c00409_ST.178::cid_164981

SMILES O=c1n(sc2ccccc12)-c1ccccc1

InChI Key InChIKey=KDMQSUUXKLZVNU-UHFFFAOYSA-N

Data  1 KI  23 IC50  12 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 46667   

TargetBeta-lactamase(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 1.66E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2013
Entry Details
PCBioAssay
TargetPhosphotransferase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 2.39E+3nMAssay Description:Excerpt from MH0882340 application (Dr. James Morris, Clemson University) Trypanosoma brucei, the digenic protozoan parasite that causes African slee...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
TargetDNA dC->dU-editing enzyme APOBEC-3G(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 6.40E+3nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetDNA dC->dU-editing enzyme APOBEC-3A(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetGlucose-6-phosphate 1-dehydrogenase(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 8.87E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details
PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 1.15E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details
PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 7.90E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2012
Entry Details
PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 9.73E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2012
Entry Details
PCBioAssay
TargetMitochondrial peptide methionine sulfoxide reductase(Bovine)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  7.93E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetGlucose-6-phosphate 1-dehydrogenase(Leuconostoc mesenteroides)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 2.50E+4nMAssay Description:Excerpt from MH082340 application (Dr. James Morris, Clemson University) Trypanosoma brucei, the digenic protozoan parasite that causes African sleep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 4.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2013
Entry Details
PCBioAssay
TargetGenome polyprotein(Hepacivirus C)
University of Wisconsin-Milwaukee

LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 1.90E+3nMpH: 7.5 T: 2°CAssay Description:Binding assays containing 25 mM MOPS pH 7.5, 1.25 mM MgCl2, 20 nM Cy5-dT15, and 200 nM NS3h_1b were incubated 5 min at RT. Following addition of indi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetPhosphoethanolamine/phosphocholine phosphatase(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 940nMAssay Description:Inhibition of PHOSPHO1 phosphoethanolamine activity (unknown origin) assessed as amount of inorganic phosphate release after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetPhosphomannomutase 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PMM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetMannose-6-phosphate isomerase(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of phosphomannose isomerase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 490nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 130nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  6.11E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50: >3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  320nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 2.01E+4nMAssay Description:Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  1.69E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetPhosphotransferase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 6.80E+3nMAssay Description:Excerpt from MH082340 application (Dr. James Morris, Clemson University) Trypanosoma brucei, the digenic protozoan parasite that causes African sleep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetPhosphomannomutase 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 3.69E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetPhosphoethanolamine/phosphocholine phosphatase(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 941nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetMannose-6-phosphate isomerase(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 6.65E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetMannose-6-phosphate isomerase(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataIC50: 2.10E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2011
Entry Details
PCBioAssay
TargetStreptokinase A(Streptococcus pyogenes M1 GAS)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  1.50E+5nMAssay Description:Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  135nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataKi:  110nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay