BDBM4669 4-Anilinoquinazoline 16::N-(2-fluoro-4-methylphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::N-(4-Methyl-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCN(C)CC1

InChI Key InChIKey=WPCUQWCGLJALCN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4669   

LigandPNGBDBM4669(N-(2-fluoro-4-methylphenyl)-6-methoxy-7-[(1-methyl...)
Affinity DataIC50: 25nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4669(N-(2-fluoro-4-methylphenyl)-6-methoxy-7-[(1-methyl...)
Affinity DataIC50: 500nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

LigandPNGBDBM4669(N-(2-fluoro-4-methylphenyl)-6-methoxy-7-[(1-methyl...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4669(N-(2-fluoro-4-methylphenyl)-6-methoxy-7-[(1-methyl...)
Affinity DataIC50: 1.35E+4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed