BDBM466939 US10800775, Example 19::isopropyl 4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate, enantiomer 2 single enantiomer, absolute configuration not known

SMILES CC(C)OC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@@H](CC#N)C1CCCC1

InChI Key InChIKey=CQRBKPCJYAAYSJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466939   

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM466939(isopropyl 4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyr...)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM466939(isopropyl 4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyr...)
Affinity DataIC50: 55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent