BDBM468342 US10806720, Compound 1024::US11648234, Compound 1024

SMILES CC(Cn1cc(F)cn1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=KETQDHYSNYBDHH-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 468342   

TargetAndrogen receptor(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468342(US10806720, Compound 1024 | US11648234, Compound 1...)
Affinity DataIC50: 464nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468342(US10806720, Compound 1024 | US11648234, Compound 1...)
Affinity DataIC50: 462nMAssay Description:Antagonist activity at recombinant human AR expressed in HEK293 cells assessed as inhibition of R1881-induced transcriptional activity measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetAndrogen receptor [633-919](Human)
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468342(US10806720, Compound 1024 | US11648234, Compound 1...)
Affinity DataIC50: 464nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetAndrogen receptor(Rat)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468342(US10806720, Compound 1024 | US11648234, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-MIB from wild-type rat AR LBD measured after 16 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed