BDBM4684 4-Anilinoquinazoline 31::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(3S)-1-methylpiperidin-3-yl]methoxy}quinazolin-4-amine

SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@H]1CCCN(C)C1

InChI Key InChIKey=JFGLOXKNWPNMQT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4684   

LigandPNGBDBM4684(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(3S)-1-me...)
Affinity DataIC50: 10nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

LigandPNGBDBM4684(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(3S)-1-me...)
Affinity DataIC50: 100nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4684(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(3S)-1-me...)
Affinity DataIC50: 500nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4684(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[(3S)-1-me...)
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed