BDBM468435 4-(2-(2-((2,2'-dichloro-3'- (1,5-dimethyl-4,5,6,7- tetrahydro-1H-imidazo[4,5- c]pyridine-2-carboxamido)- [1,1'-biphenyl]-3-yl) carbamoyl)-1-methyl- 1,4,6,7-tetrahydro-5H- imidazo[4,5-c]pyridin-5- yl)ethyl)benzoic acid 1H NMR (600 MHz, DMSO- d6) $#948; 9.95 (s, 1H), 9.95 (s, 1H), 8.31 (dd, J = 8.2, 1.5 Hz, 1H), 8.27 (dd, J = 8.3, 1.5 Hz, 1H), 7.93 (d, J = 8.3 Hz, 2H), 7.53 (t, J = 7.9, Hz, 1H), 7.51 (t, J = 7.9 Hz, 1H), 7.45 (d, J = 8.3 Hz, 2H), 7.19 (dd, J = 7.6, 1.5 Hz, 1H),::US10806785, Example 78

SMILES CN1CCc2c(C1)nc(C(=O)Nc1cccc(c1Cl)-c1cccc(NC(=O)c3nc4CN(CCc5ccc(cc5)C(O)=O)CCc4n3C)c1Cl)n2C

InChI Key InChIKey=HWKNXZDXJLPUCQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 468435   

LigandPNGBDBM468435(US10806785, Example 78 | 4-(2-(2-((2,2'-dichloro-3...)
Affinity DataIC50: 0.100nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent