BDBM472782 US10829493, Example 8::US12552795, Compound 8::US20260138986, Compound 8
SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CC2COC2)c1
InChI Key InChIKey=ZNRLUMAQXXGHLH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 472782
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:All test articles were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of all test compounds was c...More data for this Ligand-Target Pair
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:All test articles were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of all test compounds was c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of PDGFRalpha D842V mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...More data for this Ligand-Target Pair