BDBM473187 US10844038, Example 55::trans 3-((4-Amino-3-(2-aminobenzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1,2-dithiolan-4-yl benzoate

SMILES Nc1nc2cc(ccc2o1)-c1nn(CC2SSCC2OC(=O)c2ccccc2)c2ncnc(N)c12

InChI Key InChIKey=SYVPPINMBQWIQX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473187   

TargetSerine/threonine-protein kinase mTOR(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473187(US10844038, Example 55 | trans 3-((4-Amino-3-(2-am...)
Affinity DataIC50: 52nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

LigandPNGBDBM473187(US10844038, Example 55 | trans 3-((4-Amino-3-(2-am...)
Affinity DataIC50: 750nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473187(US10844038, Example 55 | trans 3-((4-Amino-3-(2-am...)
Affinity DataIC50: 750nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473187(US10844038, Example 55 | trans 3-((4-Amino-3-(2-am...)
Affinity DataIC50: 5.50E+3nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

LigandPNGBDBM473187(US10844038, Example 55 | trans 3-((4-Amino-3-(2-am...)
Affinity DataIC50: 5.50E+3nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk2(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473187(US10844038, Example 55 | trans 3-((4-Amino-3-(2-am...)
Affinity DataIC50: 5.50E+3nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent