BDBM473765 US10844077, Compound II-3

SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cnn(c2)C2CCN(CC2)C(=O)C=C)s1

InChI Key InChIKey=IMLFSAULIJRURD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473765   

TargetTyrosine-protein kinase BTK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM473765(US10844077, Compound II-3)
Affinity DataIC50: 19.9nMAssay Description:The inhibitory activities of exemplary compounds described herein against select protein kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetTyrosine-protein kinase HCK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM473765(US10844077, Compound II-3)
Affinity DataIC50: 25.3nMAssay Description:The inhibitory activities of exemplary compounds described herein against select protein kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent