BDBM473852 2-hydroxy-4-(N- isobutyl-[1,1'- biphenyl]-4- ylsulfonamido) benzoic acid::US10858316, Compound 4jc117-4

SMILES CC(C)CN(c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=GESPQVXZLMHYFH-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 473852   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473852(2-hydroxy-4-(N- isobutyl-[1,1'- biphenyl]-4- ylsul...)
Affinity DataKi:  4.11E+3nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473852(2-hydroxy-4-(N- isobutyl-[1,1'- biphenyl]-4- ylsul...)
Affinity DataKi:  4.11E+3nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473852(2-hydroxy-4-(N- isobutyl-[1,1'- biphenyl]-4- ylsul...)
Affinity DataKi:  4.11E+3nMAssay Description:Inhibition of FITC-labelled BAK BH3 peptide to 6His-MBP tagged recombinant human MCL-1 (172 to 327 residues) expressed in Escherichia coli assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473852(2-hydroxy-4-(N- isobutyl-[1,1'- biphenyl]-4- ylsul...)
Affinity DataKi:  1.08E+4nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM473852(2-hydroxy-4-(N- isobutyl-[1,1'- biphenyl]-4- ylsul...)
Affinity DataKi:  1.08E+4nMAssay Description:Binding affinity to BCL-xL (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed