BDBM473863 4-(N- cyclopentyl- naphthalene- 2-sulfonamido)-2- hydroxybenzoic acid::US10858316, Compound LC-4-083::US10858316, Compound LC-4-104

SMILES OC(=O)c1ccc(cc1O)N(C1CCCC1)S(=O)(=O)c1ccc2ccccc2c1

InChI Key InChIKey=DJNCDDPHSXBDHZ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 473863   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473863(4-(N- cyclopentyl- naphthalene- 2-sulfonamido)-2- ...)
Affinity DataKi:  1.76E+3nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473863(4-(N- cyclopentyl- naphthalene- 2-sulfonamido)-2- ...)
Affinity DataKi:  1.76E+3nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473863(4-(N- cyclopentyl- naphthalene- 2-sulfonamido)-2- ...)
Affinity DataKi:  1.91E+3nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473863(4-(N- cyclopentyl- naphthalene- 2-sulfonamido)-2- ...)
Affinity DataKi:  2.47E+4nMAssay Description:Inhibition of FITC-labelled BAK BH3 peptide to 6His-MBP tagged recombinant human MCL-1 (172 to 327 residues) expressed in Escherichia coli assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM473863(4-(N- cyclopentyl- naphthalene- 2-sulfonamido)-2- ...)
Affinity DataKi:  2.47E+4nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent