BDBM474199 6-methyl-3-(tetrahydro-2H-pyran- 4-yl)-7-(thiophen-3- ylmethyl)imidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 79::US10905688, Example 79

SMILES Cc1cn2c(ncc2c(=O)n1Cc1ccsc1)C1CCOCC1

InChI Key InChIKey=VRSLRMWKAICODM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 474199   

LigandPNGBDBM474199(US10905688, Example 79 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474199(US10905688, Example 79 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

LigandPNGBDBM474199(US10905688, Example 79 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 112nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474199(US10905688, Example 79 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 112nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

LigandPNGBDBM474199(US10905688, Example 79 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 228nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

LigandPNGBDBM474199(US10905688, Example 79 | 6-methyl-3-(tetrahydro-2H...)
Affinity DataIC50: 228nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent