BDBM474227 5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1,2,3-triazol-2-yl)-[1,2,4]triazolo[1,5-c] pyrimidin-8-yl]-l -methyl-1,2-dihydropyridin-2-one::US10858365, Compound 25::US11629147, Cmpd. 25

SMILES Cn1cc(ccc1=O)-c1c(nc(N)n2nc(Cc3c(F)cccc3F)nc12)-n1nccn1

InChI Key InChIKey=NOYVLVDEKLNKFK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474227   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474227(5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1...)
Affinity DataIC50: 1.40nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474227(5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1...)
Affinity DataIC50: 7.90nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474227(5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1...)
Affinity DataIC50: 20nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
TBA

US Patent
LigandPNGBDBM474227(5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1...)
Affinity DataIC50: 582nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Mouse)
TBA

US Patent
LigandPNGBDBM474227(5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1...)
Affinity DataIC50: 30nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474227(5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1...)
Affinity DataIC50: 21nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474227(5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1...)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474227(5-[5-amino-2-[(2,6-difluorophenyl)methyl]-7-(2 H-1...)
Affinity DataIC50: 7.90nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent