BDBM474239 2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyridin-4-yl)-7-(oxazol-2-yl)-[1,2,4]triazolo[1,5-c] pyrimidin-5-amine::US10858365, Compound 85::US11629147, Cmpd. 85

SMILES Nc1nc(-c2ncco2)c(-c2ccnc(OC(F)F)c2)c2nc(Cc3c(F)cccc3F)nn12

InChI Key InChIKey=KYYWDRHHODWIJU-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474239   

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474239(2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyri...)
Affinity DataIC50: 5.5nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474239(2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyri...)
Affinity DataIC50: 5.40nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474239(2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyri...)
Affinity DataIC50: 15nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
TBA

US Patent
LigandPNGBDBM474239(2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyri...)
Affinity DataIC50: 48nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Mouse)
TBA

US Patent
LigandPNGBDBM474239(2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyri...)
Affinity DataIC50: 11nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474239(2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyri...)
Affinity DataIC50: 27nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
TBA

US Patent
LigandPNGBDBM474239(2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyri...)
Affinity DataIC50: 5.5nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
TBA

US Patent
LigandPNGBDBM474239(2-(2,6-difluorobenzyl)-8-(2-(difluoromethoxy) pyri...)
Affinity DataIC50: 5.40nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent