BDBM474352 (S)-6-((R)-(4-fluorophenyl)(6- (trifluoromethyl)pyridin-3-yl)methyl)-11- hydroxy-5,6-dihydro-10H- imidazo[2',1':3,4]pyrazino[1,2-b]pyridazin-10- one::US10858366, Example 20::US11453677, Example 20

SMILES Oc1c2-c3nccn3C[C@H]([C@H](c3ccc(F)cc3)c3ccc(nc3)C(F)(F)F)n2ncc1=O

InChI Key InChIKey=LDVKSYWJYVRSMF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474352   

TargetPolymerase acidic protein(Influenza A virus (strain A/Victoria/3/1975 H3N2))
Novartis

US Patent
LigandPNGBDBM474352(US10858366, Example 20 | (S)-6-((R)-(4-fluoropheny...)
Affinity DataIC50: 300nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetPolymerase acidic protein(Influenza A virus (strain A/Victoria/3/1975 H3N2))
Novartis

US Patent
LigandPNGBDBM474352(US10858366, Example 20 | (S)-6-((R)-(4-fluoropheny...)
Affinity DataIC50: 300nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent