BDBM474367 (S)-6-((S)-(3-bromophenyl)(4- fluorophenyl)methyl)-11-hydroxy-5,6-dihydro- 10H-imidazo[2',1':3,4]pyrazino[1,2- b]pyridazin-10-one::US10858366, Example 30::US11453677, Example 30

SMILES Oc1c2-c3nccn3C[C@H]([C@@H](c3ccc(F)cc3)c3cccc(Br)c3)n2ncc1=O

InChI Key InChIKey=KDOKEUIPXDKMQL-UHFFFAOYSA-N

Data  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 474367   

TargetPolymerase acidic protein(Influenza A virus (strain A/Victoria/3/1975 H3N2))
Novartis

US Patent
LigandPNGBDBM474367(US10858366, Example 30 | (S)-6-((S)-(3-bromophenyl...)
Affinity DataIC50: 10nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetNeuraminidase(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Novartis

US Patent
LigandPNGBDBM474367(US10858366, Example 30 | (S)-6-((S)-(3-bromophenyl...)
Affinity DataEC50:  45nMAssay Description:For influenza NA assays, MDCK cells were plated in Phenol Red-free DMEM (Gibco) supplemented with 2 mM L-Glutamine, 1% sodium pyruvate (Cellgro, Mana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetNeuraminidase(Influenza A virus (strain A/Memphis/1/1971 H3N2))
Novartis

US Patent
LigandPNGBDBM474367(US10858366, Example 30 | (S)-6-((S)-(3-bromophenyl...)
Affinity DataEC50:  190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetNeuraminidase(Influenza A virus (A/duck/Hubei/W1/2004(H9N2)))
Novartis

US Patent
LigandPNGBDBM474367(US10858366, Example 30 | (S)-6-((S)-(3-bromophenyl...)
Affinity DataEC50:  65nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolymerase acidic protein(Influenza A virus (strain A/Victoria/3/1975 H3N2))
Novartis

US Patent
LigandPNGBDBM474367(US10858366, Example 30 | (S)-6-((S)-(3-bromophenyl...)
Affinity DataIC50: 10nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent