BDBM47455 US20240124450, Example 30B

SMILES COc3cccc4ncc(c2cc(OC[C@@]1(N)CCCS1)c(C#N)c(SC)c2)n34

InChI Key InChIKey=PYEWRVJBQXWXNV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 47455   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47455BDBM47455(US20240124450, Example 30B)
Affinity DataIC50: 1.20nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47455BDBM47455(US20240124450, Example 30B)
Affinity DataIC50: 2.20nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 47455BDBM47455(US20240124450, Example 30B)
Affinity DataIC50: 5.20nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent