BDBM476676 (S)-6-(9,9-Difluoro-6-(prop-1-yn-1-yl)- 9H-fluoren-3-yl)-2-imino-3,6- dimethyltetrahydropyrimidin-4(1H)-one::US10870635, Example 82

SMILES CC#Cc1ccc2c(c1)-c1cc(ccc1C2(F)F)[C@]1(C)CC(=O)N(C)C(=N)N1

InChI Key InChIKey=RJFGEEPBVTVJQR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476676   

TargetBeta-secretase 1(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476676(US10870635, Example 82 | (S)-6-(9,9-Difluoro-6-(pr...)
Affinity DataIC50: 300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent