BDBM477574 (R) N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)picolinamide::US10889564, Example 3

SMILES Fc1ccccc1-n1ncc2[C@@H](CCCc12)NC(=O)c1ccccn1

InChI Key InChIKey=NVQPQLKFUOFZLS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477574   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Genase Therapeutics

US Patent
LigandPNGBDBM477574(US10889564, Example 3 | (R) N-(1-(2-fluorophenyl)-...)
Affinity DataIC50: 166nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Genase Therapeutics

US Patent
LigandPNGBDBM477574(US10889564, Example 3 | (R) N-(1-(2-fluorophenyl)-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Genase Therapeutics

US Patent
LigandPNGBDBM477574(US10889564, Example 3 | (R) N-(1-(2-fluorophenyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate incubated for 60 mins by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed