BDBM477691 (R)—N8-(4-(chlorodifluoromethoxy)phenyl)-N6,4-dimethyl-3,4-dihydro-1H-benzo[4,5]imidazo[2,1-c][1,4]oxazine-6,8-dicarboxamide::US10889571, Example 32::US20240101536, Example 32

SMILES CNC(=O)c3cc(C(=O)Nc1ccc(OC(F)(F)Cl)cc1)cc4nc2COC[C@@H](C)n2c34

InChI Key InChIKey=RHFBMILGABCZCY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477691   

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477691(US10889571, Example 32 | (R)—N8-(4-(chlorodif...)
Affinity DataIC50: 0.370nMAssay Description:ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477691(US10889571, Example 32 | (R)—N8-(4-(chlorodif...)
Affinity DataIC50: 0.370nMAssay Description:The activity of the enzyme and compound inhibition was tested using an EZ reader microfluidic mobility shift assay (PerkinElmer, Waltham, MA). For in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent