BDBM477891 US10889579, Example 111

SMILES C[C@@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F)C(=O)N1CCOCC1

InChI Key InChIKey=QBRVMFURZXJSCP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477891   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477891(US10889579, Example 111)
Affinity DataIC50: 98nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477891(US10889579, Example 111)
Affinity DataIC50: 1.47E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM477891(US10889579, Example 111)
Affinity DataIC50: 3.01E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent