BDBM479186 US10894789, Compound 32

SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(C)cc1

InChI Key InChIKey=DITCCDHABXVFKR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 479186   

TargetOrexin/Hypocretin receptor type 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM479186(US10894789, Compound 32)
Affinity DataIC50: 6nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO OX1 or CHO OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM479186(US10894789, Compound 32)
Affinity DataIC50: 12nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO OX1 or CHO OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Astrazeneca

US Patent
LigandPNGBDBM479186(US10894789, Compound 32)
Affinity DataIC50: 5.00E+3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO OX1 or CHO OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Astrazeneca

US Patent
LigandPNGBDBM479186(US10894789, Compound 32)
Affinity DataIC50: 5.00E+3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO OX1 or CHO OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent