BDBM480517 N-(2-(4-(4-(4-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)phenyl)-1H-pyrazol-1-yl)ethyl)acetamide trifluoroacetate::US10899764, Example 43

SMILES CC(=O)NCCn1cc(cn1)-c1ccc(cc1)N1CCC(CC1)C1c2c(cccc2F)-c2cncn12

InChI Key InChIKey=NDLPMYFSSFPRIL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480517   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480517(N-(2-(4-(4-(4-(6-fluoro-5H-imidazo[5,1-a]isoindol-...)
Affinity DataIC50: 63.3nMAssay Description:IDO1: For testing, 24 μL of enzyme (IDO1) was diluted 100 times with 50 mM KPB to 2400 μL. The concentration of the enzyme solution was 2.6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480517(N-(2-(4-(4-(4-(6-fluoro-5H-imidazo[5,1-a]isoindol-...)
Affinity DataIC50: 247nMAssay Description:TDO: For testing, 24 μL of enzyme (TDO) was diluted 100 times with 50 mM KPB to 2400 μL. The concentration of the enzyme solution was 2.6 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent