BDBM480609 1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquinolin-8-yl)-5,7- dimethyl-3-(tetrahydro-2H- pyran-4-yl)-7,8- dihydroimidazo[1,5a] pyrazin-6(5H)-one::US10899769, Example 90a::US10899769, Example 90b

SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1

InChI Key InChIKey=UMQADUCCACBHKD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 480609   

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM480609(US10899769, Example 90b | 1-(7-fluoro-3-(1-methyl-...)
Affinity DataIC50: 1.01E+3nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM480609(US10899769, Example 90b | 1-(7-fluoro-3-(1-methyl-...)
Affinity DataIC50: 2.50E+4nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM480609(US10899769, Example 90b | 1-(7-fluoro-3-(1-methyl-...)
Affinity DataIC50: 4nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM480609(US10899769, Example 90b | 1-(7-fluoro-3-(1-methyl-...)
Affinity DataIC50: 879nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent