BDBM481125 US10906896, Cpd 404

SMILES COc1cccc(NC(=O)C2=NN=C(C2)c2cncc(c2)-c2ccnc(Nc3cc(NC(=O)c4ccc(CN5CCN(C)CC5)cc4)ccc3C)n2)c1

InChI Key InChIKey=OBLBAQUXHOPUQG-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481125   

TargetMast/stem cell growth factor receptor Kit(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM481125(US10906896, Cpd 404)
Affinity DataKi:  5.80nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM481125(US10906896, Cpd 404)
Affinity DataIC50: 100nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL2(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM481125(US10906896, Cpd 404)
Affinity DataIC50: 116nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent