BDBM481919 (3aS,6aS)-5-(4-Sulfamoyl-benzoyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid 3-chloro-5-methanesulfonyl-benzyl ester::US10913745, Example 7

SMILES CS(=O)(=O)c1cc(Cl)cc(COC(=O)C2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc(cc2)S(N)(=O)=O)c1

InChI Key InChIKey=RRXULUKPKAUVIQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 481919   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM481919(US10913745, Example 7 | (3aS,6aS)-5-(4-Sulfamoyl-b...)
Affinity DataIC50: 14.5nMAssay Description:Assay buffer (50 mM Tris-HCl, 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 0.01% Triton-X-100, pH 8.0;ATX solution: ATX (human His-tagged) stock so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
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