BDBM484229 (S)-1-(2-(1-(4-(3- chlorophenoxy)phenyl)imidazo[1,5- a]pyrazin-3-yl)pyrrolidin-1-yl)prop-2- en-1-one::US10933063, Compound 28::US11554118, Compound 28

SMILES Clc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1

InChI Key InChIKey=AHMRDGGMOAZUNG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484229   

TargetTyrosine-protein kinase BTK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484229(US10933063, Compound 28 | (S)-1-(2-(1-(4-(3- chlor...)
Affinity DataIC50: 10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent

TargetTyrosine-protein kinase BTK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484229(US10933063, Compound 28 | (S)-1-(2-(1-(4-(3- chlor...)
Affinity DataIC50: 30nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent