BDBM484231 (S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)imidazo[1,5- a]pyrazin-3-yl)pyrrolidin-1-yl)prop-2- en-1-one::US10933063, Compound 30::US11554118, Compound 30

SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccncc23)c1F

InChI Key InChIKey=CFYBPLINLQYRJH-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 484231   

TargetTyrosine-protein kinase BTK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 10nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent

TargetTyrosine-protein kinase BTK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent

TargetTyrosine-protein kinase BTK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 30nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 550nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 550nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 5.50E+3nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 5.50E+3nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 5.50E+3nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 5.50E+3nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Lyn(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent

TargetTyrosine-protein kinase Lck(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following Table shows the activity of selected compounds of this invention in the BTK, TEC, BLK, LYN, LCK inhibition assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details Article
US Patent

TargetTyrosine-protein kinase Lck(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Lyn(Human)
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484231(US10933063, Compound 30 | (S)-1-(2-(1-(4-(2-fluoro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent